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In a 2012 review, all clinical trials to date were summarized. [52] In a 2015 analysis of a double blind placebo controlled study of PEA in sciatic pain, the Numbers Needed to Treat was . Its positive influence in chronic pain, and inflammatory states such as atopic eczema, seems to originate mainly from PPAR alpha activation. [47] [51] Since 2012 a number of new trials have been published, among which studies in glaucoma. [53] [54] PEA also seems to be one of the factors responsible for the decrease in pain sensitivity during and after sport, comparable to the endogenous opiates (endorphines). [55]

Test p mast p npp

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